Probulin Probiotic Reviewed
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I was skimming through the Prime Day discounts when I happened upon this sweet gem of a probiotic bargain at which I promptly went compulsive on, and forked out about $.76 for each capsule of bacteria. However, as I looked today, I see no difference in the price, so it must not have been one of the prime day movers. But, after you read what I have to say about this product you too may want to pull the trigger on purchasing a similar probiotic product to fix all sorts of health issues you're having with metabolism, especially after stopping the harmful onslaught of excessive monosaccharides as I have. (PMID: 29899272, 18636654) It took me a heck of a lot of reading and YouTube viewing of medical lectures to finally see things as Hippocrates may have about the majority of my poor health issues originating from an unhealthy gut (PMID: 28197336). And, those who are in tune with holistic Ayurveda medicine, may even say that I’m concentrate now on the “Humors” of the body, but this would be a misunderstanding of the true microbial nature of your body and the need for good biological scavengers (a clean up crew).
If you took the time to truly focus on listening to the Sonnenburgs’ insightfulness in this brief discussion, you might see that germs are not as evil as you may have previously perceived them to be. You need not kill off your good bacteria by eating in an unconscious way, nor allowing your tongue and fear of germs to rule over your ability to have a healthy immunity creating gut. What I have discovered, after almost thirty years of battling type 2 diabetes, is that sugar tricks our tongue into convincing the mind towards overconsuming nutrient-poor foods that will result in ill health if continued unchecked. My focus, as I have learned from reading about the diets of the blue zone centenarians, is to concentrate more of my diet on those types of foods that will maximize energy production in the body and to understand how not to crave bad foods.
Mark Hyman’s Farmacy PodCast w/Dr. Todd LePine
For me, It all starts with the microbiome. Sugar, a monosaccharide, is both poisonous and highly addictive in its refined purest form with long-term hidden consequences, but our tongues will tell us differently. Here is another video that may help you learn more.
The reality is that if you are a healthy person there are more bacteria in your body than there are cells. (PMID: 28512250) There have been a mind-boggling number of Studies have been done that focus on the bad gut ills of overconsuming monosaccharides and few out in the medical establishment encouraging legislation towards the greater consumption of the microbiome-loving plant-based polysaccharides that are less costly to produce and more beneficial to human health. (PMID: 28165863) A good gut is your key to good health just as Hippocrates is thought to have taught medical students thousands of years ago. (PMID: 24388214) Below is another video to help understand why we should switch to polysaccharides.
Can you see how you can actually grow healthy by developing a good gut, or are you going to continue feeling miserable with an ever-growing list of ailments? But do it with a word of caution towards these probiotics, you can go too far in your effort and damage your gut permanently. The next video should help you to understand why you should be cautious about using a probiotic.
To put it all together and help you to understand the big picture about good nutrient absorption, please view the following video,
Now for the real nitty-gritty, what about the 12 colonies of bacteria that was physician formulated, and how do these benefit me?
Let’s look at the Supplement Facts for a listing for the colonies.
Benefits with PubMed references:
Bifidobacteria 18 Billion CFU (Colony-forming unit)
The organic acids profile, sugar metabolism, and biomass growth of Streptococcus thermophilus (St) and Bifidobacterium lactis (Bl) have been studied in pure cultures or binary co-culture (St–Bl) in skim milk either containing 40 mg/g of inulin or not. With inulin, the time required by St, Bl, and St–Bl to complete fermentation (i.e., when the pH reached 4.5) was about 14, 8, and 49% shorter than without inulin, respectively. This prebiotic also enhanced the levels of lactic and acetic acids and volatile compounds, showing a positive synbiotic effect between pre- and probiotics. In particular, the St–Bl co-culture showed final concentrations of both microorganisms about 15 and 38% higher than in their respective pure cultures, thus highlighting a clear synergistic effect between these microorganisms due to mutual interactions. In addition, the well-known bifidogenic effect of inulin was confirmed. (Food Research International, Volume 48, Issue 1, August 2012, Pages 21-27)
increase tumoricidal activity (PMID: 28245559)
improve general digestive comfort (PMID: 24056591)
decrease intestinal permeability (PMID: 24353483)
decrease lactose intolerance (PMID: 29425071)
normalize bowel movements (PMID: 25611063)
decrease IBS symptoms (PMID: 31480656)
decrease constipation (PMID: 30809523)
treat acute diarrhea (PMID: 25599772)
decrease cavity-causing bacteria in the mouth (PMID: 19193706)
fight dental caries (PMCID: PMC3747770)
reduce frequency & severity of respiratory diseases (PMID: 27495104)
increase vaccination immune response (PMID: 29090064)
increase immunity among the elderly (PMID: 11722966)
inhibit H. pylori (can cause ulcers) (PMID: 25277407)
increase T-cell activity as needed (PMID: 29255450)
strengthen the immune system (PMID: 11114680)
reduce colds and flu (PMID: 19651563)
decrease atopic dermatitis symptoms and sensitivity (PMID: 22745643)
decrease inflammatory responses (PMID: 16773690)
increase blood glucose control (PMID: 26161741)
decrease total cholesterol (PMID: 29384846)
increase HDL-cholesterol (PMID: 12209372)
B. infantis (PMID: 32481558, 23200660)
Prebiotics are non-digestible substrates that stimulate the growth of beneficial microbial populations in the intestine, especially Bifidobacterium species. Among them, fructo- and galacto-oligosaccharides (GOS) are commonly used in the food industry, especially as a supplement for infant formulas. Galacto-oligosaccharides are produced through the enzymatic conversion of lactose, a component of bovine milk. (Kefir and Greek yogurt should pop out in your mind.) Mechanistic details on the enrichment of bifidobacteria by these prebiotics are important to understand the effects of these dietary interventions. In this study, the consumption of galactooligosaccharides was studied for 22 isolates of Bifidobacterium longum subsp. infantis, one of the most representative species in the infant gut microbiota. In general, all isolates showed a vigorous growth on these oligosaccharides, but consumption of larger galactooligosaccharides was variable. Bifidobacterium infantis ATCC 15697 has five genes encoding β-galactosidases, and three of them were induced during bacterial growth on commercial galactooligosaccharides. Recombinant β-galactosidases from B. infantis ATCC 15697 displayed different preferences for β-galactosides such as 4' and 6'-galactobiose, and four β-galactosidases in this strain released monosaccharides from galactooligosaccharides. Finally, we determined the amounts of short-chain fatty acids produced by strain ATCC 15697 after growth on different prebiotics. We observed that biomass and product yields of substrate were higher for lactose and galactooligosaccharides, but the amount of acids produced per cell was larger after growth on human milk oligosaccharides. These results provide a molecular basis for galactooligosaccharide consumption in B. infantis, and also represent evidence for physiological differences in the metabolism of prebiotics that might have a differential impact on the host.
reduces acute diarrhea (rotavirus and non-rotavirus) (PMID: 22504002)
reduce or eliminate symptoms of IBS (PMID: 28166427)
B. infantis protect the vaginal canal from infection and invasion (PMID: 29684056)
establish infant microflora (PMID: 32481558)
reduce death among very low birth weight infants (PMID: 15629973)
increase immunity among very low birth weight infants (PMID: 3748663)
improve immune system efficiency (PMID: 22572827)
reduce inflammatory allergic response (PMID: 32249275)
reduce urinary oxalate (associated with kidney stones) (PMID: 11532105)
B. longum (PMID: 32481558, 32220841)
is considered to be a scavenger, possessing multiple catabolic pathways to use a large variety of nutrients to increase its competitiveness among the gut microbiota. Up to 19 types of permease exist to transport various carbohydrates with 13 being ATP-binding cassette transporters. B. longum has several glycosyl hydrolases to metabolize complex oligosaccharides for carbon and energy. This is necessary as mono- and disaccharides have usually been consumed by the time they reach the lower gastrointestinal tract where B. longum resides. In addition, B. longum can uniquely ferment galactomannan-rich natural gum using glucosaminidases and alpha-mannosidases that participate in the fermentation of glucosamine and mannose, respectively.
Oligosaccharides are a component of fibre from plant tissue. FOS and inulin are present in Jerusalem artichoke, burdock, chicory, leeks, onions, and asparagus. Inulin is a significant part of the daily diet of most of the world’s population. FOS can also be synthesized by enzymes of the fungus Aspergillus niger acting on sucrose. GOS is naturally found in soybeans and can be synthesized from lactose. FOS, GOS, and inulin are also sold as nutritional supplements.
The high number of genes associated with oligosaccharide metabolism is a result of gene duplication and horizontal gene transfer, indicating that B. longum is under selective pressure to increase its capability to compete for various substrates in the gastrointestinal tract. Furthermore, B. longum possesses hydrolases, deaminases, and dehydratases to ferment amino acids. B. longum also has bile salt hydrolases to hydrolyze bile salts into amino acids and bile acids. The function of this is not clear, although B. longum could use the amino acid products to better tolerate bile salts.
Helps fight infections (PMID: 28747822)
Might help in the treatment of anxiety (PMID: 28483500)
Stimulates immune system (PMID: 31632412)
Reduces obesity-related hepatitis (PMID: 29379536)
Earlier research evaluated using the B. longum as a delivery mechanism for chemotherapy for colon cancers (PMID: 10770636)
mostly lives in the colon (PMID: 27379055)
Are rod-shaped, gram-negative bacteria (PMID: 28480152)
One of the first bacteria to colonize an infant’s intestines (PMID: 29118049)
resistant to stomach acid and bile (PMID:18330633)
considered safe for supplementation (PMID: 28558732)
likes to ferment plant fibers and eat them (PMID: 31010241)
lactic acid and other products help stimulate the immune system and reduce inflammation (PMID: 21897224)
B. bifidum (PMID: 31717486)
infection by Helicobacter pylori (H. pylori)
restoration of intestinal bacteria after chemotherapy
lung infections
certain kinds of diarrhea
necrotizing enterocolitis, a type of infection in the intestinal lining caused by harmful bacteria
pouchitis, a complication of surgery for ulcerative colitis
Lactobacillus 1.5 Billion CFU
Others Probiotics 500 Million CFU
