Understanding the Slim-A-Trim benefits of Refined Carbohydrate restriction and intermittent fasting (Pt. 1)

August 3, 2021 Mark Spilmon

Signimu & Google & Penubag, Apache License 2.0, via Wikimedia Commons

1) Reversed insulin and leptin resistance

Please watch Dr. Jason Fung short 11 min. YouTube video below:

So, as Dr. Fung explained, a monosaccharide-heavy diet triggers the fat-storing hormone, insulin, and this forces uptake of triglyceride into adipose tissues. Insulin is the switch that makes your body store fat that your liver creates from the unnecessary sugary carbohydrates you eat. Look at the section on overconsumption illnesses on the Wikipedia page on Human Nutrition, and the positive health effect of a sugar high-fiber diet on the carbohydrate page. None fattening nutrition is the key to efficient Celular-sliming, not excessive exercise. Now watch Dr. Benjamin Bikman's 1/2 hour video on the efficacy of a ketone-centric diet eating over an insulin-triggering one. You can burn fat like a young active child and be happier with less inflammation.

But a high-fat diet is self-defeating because fatty acids are caloric dense and they also must either be stored or expelled in the form of ketones. So, how do we help the adipose tissue work to cut up the fat for the generation of ketones? Now watch this short video on how peroxisome proliferator-activated receptor-gamma (ppar-γ) triggers non-shivering thermogenesis in the transcription of proteins, organelles, and enzymes for fat conversion (beta-oxidation) and this makes your body burn the fat due to the cell’s increased need for ATP. (PMID: 22247890)

Once the peroxisomes have begun to release the triglyceride it must be transported into the mitochondria for beta-oxidation and this requires l-carnitine to do so. (So, if you consume MCT oil you will also need to consume L-carnitine to burn it up, this is why you don’t need to over-consume the MCT and require animal protein to prevent weight gain.) Please watch the short video below from Wondersofchemistry to better understand fatty acid transport into the mitochondria.

This process is occurring as we sleep through Cellular Respiration (breathing). (To understand this process better see Professor Fink’s two lectures on Cellular Respiration listed at the bottom of this webpage.) Here is a graphic representation by Kevin Nga on how exercise works to dissolve stored fat for energy but keep in mind that this happens through the cellular signaling of ppar-γ.

Now watch this video from Hussain Biology on how cell differentiation occurs once the cellular transcription process has been triggered.

However, it is the uncoupled proteins of the mitochondria that are the most important in a baby’s brown adipose tissue to keep them warm. This uncoupling molecular process to produce ATP is biochemical Non-shivering thermogenesis. (Wikipedia) Here is a simple video to help you understand this effortless event:

To have an important working understand of a peroxisome’ function in your adipose tissue’s beta-oxidation of fat, please watch the following video creation of the cellular biologist, Professor Zach Murphy, Ninja Nerd:

The video below is a detailed biological look from Dr. Spiegelman at intercellular signaling via peroxisome proliferator-activated receptors (PPARs) on adipose fat storage tissue and how this will switch adipose tissue into becoming a brown fat-burning machine when avoiding foods causing insulin spikes and inflammation. (sugar abstinent, low protein normal fat intake, increased prebiotic bulk, and intermittent fasting). (Aired June 02, 2010)

More insight in a previous talk by Dr. Jeffrey Peterson on the PPAR ligand agonists in the next video. (Aired March 11, 2009)

Summary:

My insightful research findings and thoughts?

I have discovered through extensively researching PubMed that MCT oil (chiefly decanoic acid) is an activation ligand for PPAR-y (PMID: 22039047). Also, that butyrate a short-chain fatty acid (SFA) created in the small intestine microbiome is an agonist for PPAR. (PMID: 28798125) However, my most influential finding was through a PubMed search which drew out that supplemental Conjugated linoleic acid (CLA) directly contributed to increased adipose browning and weight loss during fasting. (So, I am using this supplement to keep my weight in check. See the blog post on CLA.) (PMID: 32708786, 28245284, 28945993, 29659960) Moreover, the cell signaling ligand, decanoic acid, is also created within our bodies (found in mother’s milk) and has been found to be instrumental in developing an infant’s microbiome (PMID: 29349441,28925980). So, my research has found that low consumption of MCT oil in the daily diet is a good thing for a healthy gut. The gut and your ability to keep body fat at a tolerable level will help you achieve a long and productive life. Being active, self-sustaining, and enjoying life is of utmost importance my opinion to live as long as an Okinawan centenarian and the correct way of becoming Slim and Trim for life.

1) Reversed insulin and leptin resistance

Summary:

More videos: